Downregulator example sentences
downregulation
noun physiology biochemistry
downregulation (noun) · downregulations (plural noun)
- the reduction at the cellular level of the magnitude or rate of a physiological response or a biochemical process, especially of the expression of a gene.
- the reduction of the number or density of cell surface receptors for a physiologically active substance, causing a decrease in sensitivity in response to persistent exposure.
"Downregulator" Example Sentences
1. The researchers identified a novel downregulator of the inflammatory response.2. A key downregulator in this pathway is the enzyme, phosphatase and tensin homolog.
3. This drug acts as a potent downregulator of gene expression.
4. Further investigation is needed to fully characterize the downregulator's mechanism of action.
5. The downregulator protein binds to the promoter region, inhibiting transcription.
6. Dysregulation of this downregulator is associated with several cancers.
7. They discovered a microRNA acting as a downregulator of oncogene expression.
8. The downregulator is crucial for maintaining cellular homeostasis.
9. Identifying novel downregulators is a promising area of therapeutic research.
10. Downregulators of this pathway are potential drug targets.
11. The study highlighted the importance of this specific downregulator in disease pathogenesis.
12. This protein functions as a negative downregulator of cell growth.
13. Overexpression of the downregulator led to a significant reduction in tumor size.
14. The downregulator showed a remarkable ability to suppress inflammation.
15. We hypothesize that this molecule may act as a new downregulator of immune response.
16. The effects of the downregulator were dose-dependent.
17. This downregulator is a promising therapeutic target for inflammatory diseases.
18. Further research is required to elucidate the exact role of this downregulator.
19. The downregulator significantly reduced the levels of the target protein.
20. The study revealed a complex interplay between the downregulator and other signaling molecules.
21. Inhibition of the downregulator led to an increase in disease severity.
22. The downregulator’s mechanism is still not completely understood.
23. This is a novel downregulator never before described.
24. Are there other potential downregulators in this cellular pathway?
25. This particular downregulator is highly specific to its target.
26. The team investigated the effectiveness of this downregulator in vivo.
27. The downregulator is implicated in various disease processes.
28. The clinical significance of this downregulator warrants further study.
29. Deficiency in this downregulator leads to a severe disease phenotype.
30. The downregulator is encoded by gene X.
31. This is a potent and specific downregulator of cytokine production.
32. This downregulator represents a new therapeutic opportunity.
33. The downregulator acts by competing with the activator protein.
34. The expression of the downregulator is tightly regulated.
35. We observed a strong correlation between downregulator expression and disease outcome.
36. The downregulator’s impact on cellular metabolism was significant.
37. Genetic manipulation of the downregulator altered cellular behavior.
38. The downregulator is a promising biomarker for early disease detection.
39. This downregulator could offer a novel treatment strategy.
40. The interaction between the activator and downregulator is critical.
41. The downregulator plays a key role in signal transduction.
42. The downregulator may offer new diagnostic capabilities.
43. This downregulator is involved in a complex regulatory network.
44. The downregulator is expressed predominantly in certain tissues.
45. The effects of the downregulator were long-lasting.
46. Targeting the downregulator may improve treatment efficacy.
47. The downregulator’s activity is influenced by various factors.
48. The downregulator is part of a larger signaling cascade.
49. The discovery of this downregulator has significant implications.
50. This downregulator is a potential target for personalized medicine.
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