"Fibrillarin" Example Sentences
1. The fibrillarin protein plays a crucial role in ribosome assembly.
2. Mutations in the fibrillarin gene have been linked to several diseases.
3. Fibrillarin is predominantly found in the nucleolus.
4. The activity of fibrillarin is regulated by post-translational modifications.
5. Fibrillarin is highly conserved across various species.
6. Knocking out fibrillarin expression results in impaired growth and development.
7. Fibrillarin interacts with several other proteins to carry out its functions.
8. The crystal structure of fibrillarin revealed key functional domains.
9. Fibrillarin acts as a methyltransferase on specific ribosomal RNA residues.
10. The absence of fibrillarin leads to defects in pre-rRNA processing.
11. Fibrillarin deficiency is associated with certain forms of cancer.
12. Small RNA molecules can modulate fibrillarin expression in cells.
13. Fibrillarin is a component of the Cajal body.
14. The levels of fibrillarin expression are affected by cellular stress responses.
15. Fibrillarin activity is essential for proper ribosome biogenesis.
16. The increased expression of fibrillarin has been observed in ageing cells.
17. Fibrillarin is a promising therapeutic target for certain genetic disorders.
18. Fibrillarin can interact with mRNA molecules to regulate their translation.
19. The localization of fibrillarin within the nucleolus can be altered by specific signals.
20. Several drugs have been identified that target fibrillarin function.
21. The fibrillarin protein undergoes conformational changes during its activity.
22. Fibrillarin expression plays a role in the differentiation of certain cell types.
23. The presence of fibrillarin can modulate the activity of certain RNA-binding proteins.
24. Fibrillarin can act as a chaperone for certain RNA molecules.
25. The distribution of fibrillarin in the nucleolus can differ between cell types.
26. Dysfunction of fibrillarin has been implicated in various neuromuscular diseases.
27. Fibrillarin is involved in the surveillance of certain RNA transcripts.
28. The fibrillarin protein has been implicated in the maintenance of genome stability.
29. Fibrillarin is involved in the formation of certain non-coding RNA molecules.
30. The fibrillarin protein can oligomerize to form higher-order structures.
Common Phases
1.
Fibrillarin is a protein present in the nucleolus;
2.
Fibrillarin is involved in the processing and maturation of ribosomal RNA;
3.
Fibrillarin interacts with numerous other proteins in the nucleolus;
4.
Fibrillarin is highly conserved and found in all eukaryotes studied;
5.
Fibrillarin is essential for cell viability and perturbations in
fibrillarin expression can lead to disease;
6.
Fibrillarin is also implicated in the regulation of gene expression outside of the nucleolus;
7.
Fibrillarin can serve as a diagnostic marker for certain autoimmune diseases.