"Importin" Example Sentences
1. The nuclear import receptor importin alpha facilitates the transportation of nuclear proteins.
2. The interaction between importin beta and FG nucleoporins is essential for nuclear import.
3. Importin binding to RanGTP is crucial for the release of cargo in the nucleus.
4. Importin alpha recognizes a nuclear localization signal (NLS) on cargo proteins for nuclear import.
5. The cytoplasmic protein dynein facilitates the transport of importin alpha-bound cargo to the nuclear envelope.
6. The nuclear pore complex allows importin beta-cargo complexes to be transported selectively into the nucleus.
7. The importin beta/RanGTP complex forms a lattice structure on the nuclear envelope.
8. Importin alpha-1 regulates the nuclear import of transcription factor SOX11.
9. The use of importin inhibitors can provide targeted therapy for cancer treatment.
10. The importin pathway is conserved across eukaryotes.
11. The importin-8 protein facilitates the nuclear localization of RNA.
12. Importin-related proteins also play a role in promoting the export of RNA from the nucleus to the cytoplasm.
13. Certain viruses have evolved to hijack the importin system to promote their own replication within the nucleus.
14. The binding of RanGTP to importin beta promotes its export from the nucleus.
15. The nuclear import of RNA metabolism-associated proteins is mediated by importin beta-1a.
16. Mutations in importin alpha can lead to a variety of developmental disorders.
17. The molecular chaperone HSP90 can regulate the nuclear translocation of importin alpha.
18. Knockdown of the importin alpha-5 gene can impair neuronal differentiation.
19. Importin alpha can bind to chromatin and regulate the expression of certain genes.
20. The importin pathway can be disrupted by some environmental toxins.
21. There are several isoforms of importin alpha, each with different substrate specificities.
22. The importin pathway can also regulate the localization of membrane proteins.
23. Importin-β11 is involved in the nuclear import of histone H1.
24. Importin beta-1 mediates the nuclear import of the transcription factor STAT3.
25. The N-terminal domain of importin-α is responsible for cargo binding.
26. Importin-α7 is involved in the nuclear import of the transcription factor p65.
27. The importin pathway is a target for the development of antiviral drugs.
28. The importin system is regulated by a variety of post-translational modifications.
29. The interaction between importin alpha-1 and the cargo protein KAP1 is regulated by phosphorylation.
30. The nuclear localization signal of importin alpha can be masked by phosphorylation, preventing its binding to cargo proteins.
Common Phases
Importin is a protein that plays an important role in the transport of proteins through the nuclear pores;
Importin recognizes the nuclear localization signal of the proteins being transported; The
importin-protein complex then enters the nucleus through the nuclear pore complex; Once inside the nucleus, the
importin releases the imported protein;
Importin then returns to the cytoplasm to repeat the process; Defects in
importin function can lead to a variety of diseases.