"Topoisomerase" Example Sentences
1. Topoisomerase is a crucial enzyme in DNA replication.
2. The function of topoisomerase is to remove knotting and tangling in DNA strands.
3. Some antibiotics target topoisomerase as a mechanism to stop bacterial growth.
4. Topoisomerase inhibitors have been used in cancer therapy.
5. The activity of topoisomerase can be disrupted by certain chemicals.
6. The human genome contains seven distinct topoisomerase enzymes.
7. Topoisomerase II is responsible for resolving DNA supercoils.
8. Topoisomerase IV plays a role in DNA segregation during cell division.
9. Topoisomerase I is important for preserving genome integrity.
10. Mutations in topoisomerase genes can lead to genetic disorders.
11. Topoisomerase dysfunction has been implicated in aging and neurodegenerative diseases.
12. Topoisomerase is involved in the regulation of gene expression.
13. Several structural studies have shed light on the mechanism of topoisomerase action.
14. Topoisomerase inhibitors can be used in combination with other chemotherapy drugs.
15. Some bacteria have developed resistance to topoisomerase inhibitors.
16. Topoisomerase is conserved in all domains of life.
17. The discovery of topoisomerase revolutionized the field of molecular biology.
18. Certain genetic variations can affect the activity of topoisomerase enzymes.
19. Topoisomerase is a potential target for new drug development.
20. Scientists are exploring the role of topoisomerase in epigenetics.
21. Topoisomerase has been linked to DNA damage repair processes.
22. Topoisomerase can introduce single or double strand breaks in DNA.
23. Topoisomerase is involved in the formation and resolution of DNA knots.
24. The activity of topoisomerase is modulated by various signaling pathways.
25. Inhibition of topoisomerase can lead to accumulation of DNA damage.
26. Various biochemical and biophysical techniques have been used to study topoisomerase.
27. Acidic residues are important for the catalytic activity of topoisomerase.
28. Topoisomerase has been studied in both prokaryotic and eukaryotic systems.
29. Topoisomerase plays a role in maintaining chromosomal stability.
30. Inhibitors of topoisomerase have been used in veterinary medicine.
Common Phases
1.
Topoisomerase enzymes alter the topology of DNA;
2.
Topoisomerase inhibitors prevent DNA replication and cell division;
3. DNA gyrase is a type of
topoisomerase;
4.
Topoisomerase II is involved in chromosome condensation and segregation during cell division;
5.
Topoisomerase IV is required for bacterial viability and is targets of antibiotics.