"Abetalipoproteinemias" Example Sentences
1. Abetalipoproteinemias are a rare genetic disorder that affects lipid metabolism.
2. The characteristic feature of abetalipoproteinemias is the absence of apolipoprotein B.
3. Abetalipoproteinemias can lead to malabsorption of dietary fats and fat-soluble vitamins.
4. Diagnosis of abetalipoproteinemias often involves genetic testing and lipid profile analysis.
5. Management of abetalipoproteinemias includes dietary modification and supplementation of fat-soluble vitamins.
6. Abetalipoproteinemias can cause neurological symptoms like developmental delay and ataxia.
7. Individuals with abetalipoproteinemias may experience fat accumulation in the liver.
8. There is currently no cure for abetalipoproteinemias.
9. Abetalipoproteinemias are also known as Bassen-Kornzweig syndrome.
10. Abetalipoproteinemias are typically inherited in an autosomal recessive manner.
11. Untreated abetalipoproteinemias can result in severe complications like retinopathy and neuropathy.
12. The pathophysiology of abetalipoproteinemias involves impaired intestinal and hepatic lipid transport.
13. Abetalipoproteinemias can be distinguished from other lipid metabolic disorders such as familial hypercholesterolemia.
14. The incidence of abetalipoproteinemias is estimated to be around 1 in 100,000 individuals.
15. Abetalipoproteinemias are more commonly diagnosed in childhood or early adolescence.
16. Abetalipoproteinemias may cause symptoms like muscle weakness and neuropathic pain.
17. Treatment of abetalipoproteinemias involves strict adherence to a low-fat, high-protein dietary regimen.
18. Abetalipoproteinemias can lead to growth failure and delayed puberty.
19. Complications of abetalipoproteinemias may include liver or kidney dysfunction.
20. Abetalipoproteinemias have been associated with increased risk for certain types of cancer.
21. Abetalipoproteinemias are caused by mutations in the MTP or APOB genes.
22. In some cases, abetalipoproteinemias may be mistaken for celiac disease due to malabsorption symptoms.
23. The prognosis for individuals with abetalipoproteinemias is generally good with proper management.
24. Abetalipoproteinemias may increase risk of atherosclerosis due to abnormal lipid metabolism.
25. Genetic counseling is recommended for individuals with abetalipoproteinemias and their family members.
26. Abetalipoproteinemias are often first diagnosed based on clinical symptoms and laboratory findings.
27. Individuals with abetalipoproteinemias may experience symptoms like night blindness and sensitivity to light.
28. Abetalipoproteinemias can affect multiple organ systems including the brain, liver, and spleen.
29. Management of abetalipoproteinemias also involves regular monitoring of liver function and lipid levels.
30. Treatment of abetalipoproteinemias may involve supplementation of vitamin E and other antioxidants.
Common Phases
1. Abetalipoproteinemia is a rare genetic disorder that affects lipid metabolism;
2. The condition is characterized by the absence of certain lipoproteins in the blood;
3. Individuals with abetalipoproteinemia experience malabsorption of lipids, leading to a variety of symptoms;
4. Symptoms can include poor growth and development, muscle weakness, and neurological conditions;
5. Treatment for abetalipoproteinemia is focused on managing symptoms and preventing complications.