"Aromatase" Example Sentences
1. Aromatase can convert testosterone to estrogen in the body.
2. The aromatase inhibitor medication was prescribed to block the conversion of testosterone.
3. Research has shown that aromatase plays a key role in breast cancer development.
4. The expression of aromatase is regulated by various factors including stress.
5. Aromatase-deficient mice displayed altered behavior compared to wild-type mice.
6. High levels of aromatase have been linked to polycystic ovary syndrome.
7. Aromatase inhibitors are commonly used to treat hormone receptor-positive breast cancer.
8. The protein structure of aromatase consists of 12 transmembrane helices.
9. A study found that aromatase expression in the brain was associated with aggressive behavior in mice.
10. Inhibiting the action of aromatase has been shown to decrease the incidence of prostate cancer.
11. Aromatase activity is highest in the ovaries and testicles.
12. Studies have shown that aromatase inhibitors can improve bone density in postmenopausal women.
13. Aromatase deficiency has been found to cause delayed puberty and bone maturation.
14. The role of aromatase in estrogen biosynthesis has been extensively studied.
15. Aromatase is a cytochrome P450 enzyme that catalyzes the conversion of androgens to estrogens.
16. Aromatase expression in adipose tissue has been linked to obesity and insulin resistance.
17. The use of aromatase inhibitors can cause hot flashes and joint pain in some patients.
18. Aromatase activity is highest during fetal development.
19. Aromatase inhibitors have been shown to decrease the risk of breast cancer recurrence in postmenopausal women.
20. Aromatase gene mutations can cause aromatase excess syndrome.
21. Aromatase is present in both males and females but is more highly expressed in females.
22. The development of aromatase inhibitors has revolutionized the treatment of hormone-positive breast cancer.
23. Aromatase inhibitors are not effective in treating estrogen receptor-negative breast cancer.
24. The regulation of aromatase activity is complex and involves multiple factors.
25. Aromatase inhibitors block the action of aromatase by binding to the active site of the enzyme.
26. Aromatase activity is regulated by estrogen through a feedback mechanism.
27. Aromatase inhibitors have been shown to decrease the risk of contralateral breast cancer in high-risk patients.
28. Aromatase expression in the brain is highest in the hippocampus and amygdala.
29. Aromatase inhibitors can have adverse effects on bone health if used long-term.
30. Genetic variants in the aromatase gene have been associated with increased risk of breast cancer.
Common Phases
1.
Aromatase inhibitors prevent the conversion of testosterone into estrogen;
2. High levels of
aromatase activity are associated with breast cancer;
3.
Aromatase catalyzes the final step in estrogen biosynthesis;
4.
Aromatase-mediated estrogen synthesis plays a critical role in reproductive physiology;
5.
Aromatase deficiency results in virilization in males and abnormal ovarian function in females.