Caspase example sentences

"Caspase" Example Sentences

1. The caspase family of proteases plays a crucial role in programmed cell death.
2. Caspase activation is essential for apoptosis to occur.
3. Inhibition of caspase activity can promote tumor growth.
4. The activation of caspase-3 is a hallmark of apoptosis.
5. Caspase-8 is crucial for extrinsic apoptosis signaling.
6. Caspase-9 is important for intrinsic apoptosis signaling.
7. Caspase-12 is involved in the endoplasmic reticulum stress response.
8. Cleaved caspase-7 is a marker of apoptosis.
9. The regulation of caspase activity is complex and still not fully understood.
10. Caspase inhibitors have therapeutic potential in treating cancer and neurodegenerative diseases.
11. Caspase-mediated cleavage of PARP promotes apoptosis.
12. Caspase-1 plays a key role in regulating inflammation.
13. Active caspase-2 is involved in DNA damage response pathways.
14. An imbalance in caspase activity can lead to pathological cell death.
15. Caspase activation is tightly regulated by post-translational modifications.
16. Caspase-6 is involved in cleaving the huntingtin protein in Huntington's disease.
17. Caspase-11 is important for inflammasome activation.
18. Cleaved caspase-4 is a biomarker for detecting sepsis.
19. The involvement of caspases in pyroptosis is a rapidly growing field of research.
20. Caspase-13 is a novel caspase involved in regulating inflammatory responses.
21. Caspase-14 is important for skin barrier function and homeostasis.
22. Overexpression of caspase-10 has been linked to certain types of cancer.
23. The development of caspase inhibitors as potential therapeutics is an active area of research.
24. Caspase-mediated processing of gasdermin D is involved in pyroptosis.
25. Caspase-independent apoptosis can occur through pathways such as necroptosis.
26. The role of caspases in autophagy is just beginning to be elucidated.
27. Mutations in caspase genes have been implicated in the pathogenesis of certain diseases.
28. Caspase-7 is involved in cleaving cytoskeletal proteins during apoptosis.
29. The caspase cascade is a well-established pathway for the initiation of apoptosis.
30. The discovery of new caspases and their functions continues to expand our understanding of cell death.

Common Phases

cleavage of PARP; activation of caspase-3; induction of apoptosis; caspase-dependent pathway; caspase-mediated cell death