"Ectophosphodiesterase" Example Sentences
1. Ectophosphodiesterase is a key enzyme in the degradation of extracellular DNA.
2. The activity of ectophosphodiesterase is essential for the regulation of purinergic signaling.
3. Measurement of ectophosphodiesterase activity has been proposed as a diagnostic marker for various diseases.
4. Ectophosphodiesterase-mediated hydrolysis of lipopolysaccharides contributes to host defense against bacterial infections.
5. Inhibition of ectophosphodiesterase activity can lead to alterations in intracellular signaling pathways.
6. Ectophosphodiesterase expression is detected in various tissues including lung and liver.
7. The role of ectophosphodiesterase in cancer progression and metastasis is currently being investigated.
8. Ectophosphodiesterase inhibitors are being developed as potential therapeutic agents for various diseases.
9. The mechanism of ectophosphodiesterase-mediated DNA degradation involves a two-step process of endonucleolytic cleavage followed by phophodiesterase activity.
10. Ectophosphodiesterase activity is involved in the degradation of extracellular nucleotides, which play a role in cell signaling and immune responses.
11. Ectophosphodiesterase activity has been shown to be altered in certain neurological disorders, such as Alzheimer's disease.
12. Ectophosphodiesterase expression is known to be upregulated in response to various stress stimuli including hypoxia and inflammation.
13. The crystal structure of ectophosphodiesterase has been determined, revealing insights into its catalytic mechanism.
14. A high-throughput screening assay has been developed to identify ectophosphodiesterase inhibitors.
15. The therapeutic potential of ectophosphodiesterase inhibitors is being explored in preclinical models of inflammatory bowel disease.
16. Ectophosphodiesterase activity has been implicated in the pathogenesis of chronic obstructive pulmonary disease.
17. The pharmacokinetics of ectophosphodiesterase inhibitors are being studied in animal models to inform dosing strategies for clinical trials.
18. Ectophosphodiesterase has been identified as a prognostic marker for survival in pancreatic cancer patients.
19. The relationship between ectophosphodiesterase activity and immune cell function is an area of ongoing research.
20. The effects of environmental pollutants on ectophosphodiesterase activity and expression are being investigated.
21. Ectophosphodiesterase inhibitors have been shown to attenuate neuroinflammation and improve cognitive function in animal models of Alzheimer's disease.
22. Ectophosphodiesterase activity is involved in the catabolism of adenosine, a key modulator of immune cell function.
23. Genetic studies have identified variants in the ectophosphodiesterase gene that are associated with susceptibility to inflammatory bowel disease.
24. Ectophosphodiesterase activity has been shown to be upregulated in response to viral infections, potentially contributing to antiviral immune responses.
25. The regulation of ectophosphodiesterase activity by extracellular pH and other factors is an area of ongoing investigation.
26. Ectophosphodiesterase inhibitors have been identified as potential adjuvants to enhance the efficacy of cancer immunotherapies.
27. Ectophosphodiesterase activity has been implicated in the regulation of blood pressure through its role in the metabolism of nucleotides released by endothelial cells.
28. The role of ectophosphodiesterase in wound healing and tissue repair is an area of ongoing research.
29. Ectophosphodiesterase activity has been shown to be altered in patients with rheumatoid arthritis, suggesting a potential role in disease pathogenesis.
30. The development of ectophosphodiesterase-targeted imaging agents could enable non-invasive monitoring of the activity and expression of this enzyme in vivo.
Common Phases
1.
Ectophosphodiesterase is involved in the hydrolysis of phosphodiester bonds.
2. The expression of
ectophosphodiesterase is regulated by various factors.
3.
Ectophosphodiesterase activity is important for the metabolism of extracellular nucleotides.
4. Deficiency of
ectophosphodiesterase can lead to pathological conditions.
5.
Ectophosphodiesterase plays a role in modulating signal transduction pathways.
6.
Ectophosphodiesterase is a potential therapeutic target for various diseases.
7. The function of
ectophosphodiesterase is conserved across different species.
8.
Ectophosphodiesterase inhibitors have been developed for pharmacological intervention.
9.
Ectophosphodiesterase has been implicated in immune system regulation.
10.
Ectophosphodiesterase is an enzyme that catalyzes the breakdown of phosphodiester bonds in extracellular nucleotides.