"Endoplasmic" Example Sentences
1. The endoplasmic reticulum is a network of flattened sacs and tubules within the cytoplasm of eukaryotic cells.
2. The function of the endoplasmic reticulum is to transport proteins and lipids throughout the cell.
3. Rough endoplasmic reticulum has ribosomes attached to its surface, while smooth endoplasmic reticulum does not.
4. The endoplasmic reticulum is responsible for modifying and folding newly synthesized proteins.
5. Some enzymes involved in drug metabolism are located in the smooth endoplasmic reticulum of liver cells.
6. The endoplasmic reticulum plays a crucial role in calcium storage and signaling within the cell.
7. Mutations in genes encoding endoplasmic reticulum proteins can lead to a variety of disorders and diseases.
8. The Golgi apparatus is closely associated with the endoplasmic reticulum, and together they form the secretory pathway of the cell.
9. Autophagy involves the formation of a double-membrane structure that engulfs cytoplasmic components and delivers them to the lysosome for degradation, with some intermediates passing through the endoplasmic reticulum.
10. The ERGIC (endoplasmic reticulum-Golgi intermediate compartment) is a subcellular organelle that serves as the transition point between the endoplasmic reticulum and the Golgi apparatus.
11. The unfolded protein response is a cellular stress response that is activated when the endoplasmic reticulum is overwhelmed by a buildup of misfolded proteins.
12. The protein folding activity of the endoplasmic reticulum can be disrupted by environmental factors such as heat, toxins, and oxidative stress.
13. The endoplasmic reticulum can be visualized using fluorescent dyes or antibody labeling techniques.
14. The endoplasmic reticulum is one of the most extensive organelles in a eukaryotic cell, and its surface area can be increased by the formation of tubules and cisternae.
15. The presence of disulfide bonds in proteins produced in the endoplasmic reticulum can confer stability and regulate their activity.
16. Some proteins destined for lysosomal degradation are transported from the endoplasmic reticulum to the Golgi apparatus and then to the lysosome via the late endosome.
17. The endoplasmic reticulum membrane is composed of lipids that are synthesized and modified within the organelle itself.
18. Studies have shown that perturbations in the endoplasmic reticulum homeostasis can contribute to the development of neurodegenerative diseases such as Alzheimer's and Parkinson's.
19. Specialized cells such as muscle cells and certain endocrine cells contain a network of sarcoplasmic or endoplasmic reticulum that is adapted for specific functions.
20. The endoplasmic reticulum network can be disrupted by certain genetic mutations that result in abnormal protein aggregation and can lead to diseases such as cystic fibrosis and alpha-1 antitrypsin deficiency.
21. The lumen of the endoplasmic reticulum contains molecular chaperones that assist with protein folding and prevent misfolded protein accumulation.
22. The endoplasmic reticulum can also synthesize and modify membrane lipids such as phospholipids and cholesterol.
23. The ribosomes attached to the rough endoplasmic reticulum are responsible for translating proteins destined for secretion or incorporation into cellular membranes.
24. The Golgi apparatus receives vesicles containing proteins and lipids from the endoplasmic reticulum and sorts them for delivery to different parts of the cell or for export out of the cell.
25. Some viral infections can disrupt the normal functioning of the endoplasmic reticulum in host cells, leading to immune evasion and viral replication.
26. The endoplasmic reticulum is a crucial component of the quality control mechanisms that ensure that only properly folded and functional proteins are transported to their destinations within the cell.
27. The length and shape of the endoplasmic reticulum can be influenced by the cytoskeletal network of microtubules and intermediate filaments within the cell.
28. Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein can lead to defects in endoplasmic reticulum quality control and abnormal protein folding.
29. The endoplasmic reticulum is also involved in the biosynthesis of sterols such as cholesterol and steroid hormones in certain cell types.
30. The endoplasmic reticulum and Golgi apparatus are two major protein trafficking organelles of the eukaryotic cell.
Common Phases
1.
Endoplasmic reticulum is responsible for protein synthesis;
2.
Endoplasmic reticulum is the site of lipid biosynthesis;
3.
Endoplasmic reticulum aids in the detoxification of harmful substances;
4.
Endoplasmic reticulum is responsible for the transportation of molecules within the cell.