"Polyadenylation" Example Sentences
1. Polyadenylation is a mechanism that plays a critical role in regulating gene expression.
2. The addition of a poly(A) tail through polyadenylation is essential for mRNA stability.
3. Polyadenylation occurs in the nucleus and involves the cleavage of the pre-mRNA.
4. The length of the poly(A) tail added during polyadenylation varies between different transcripts.
5. Alterations in polyadenylation can lead to changes in mRNA stability and gene expression.
6. The identification of multiple polyadenylation sites within a single gene suggests versatility in gene expression.
7. Polyadenylation is required for successful export of mature mRNA from the nucleus to the cytoplasm.
8. Polyadenylation enhances the efficiency of translation initiation by recruiting ribosomes to the mRNA.
9. Alternative polyadenylation can generate transcripts with different coding potential or stability.
10. Differential polyadenylation can lead to tissue-specific expression patterns.
11. The selection of polyadenylation site is influenced by specific sequences within the pre-mRNA.
12. Partial polyadenylation can lead to the production of truncated transcripts.
13. Terminal exon exclusion is a form of alternative polyadenylation that can generate transcripts with distinctive properties.
14. Polyadenylation has roles beyond mRNA regulation, including in microRNA processing.
15. Alternative polyadenylation of certain genes has been linked to diseases such as cancer.
16. The regulation of polyadenylation is an important mechanism in controlling gene expression during development.
17. The location of polyadenylation signals within the pre-mRNA can affect the efficiency of poly(A) tail addition.
18. Most protein coding genes undergo constitutive polyadenylation, meaning the same poly(A) site is used in all tissues and circumstances.
19. The poly(A) tail added during polyadenylation facilitates the attachment of ribosomes to the mRNA.
20. The choice of polyadenylation site can influence the stability of the resulting mRNA.
21. Alternative polyadenylation can generate transcripts with different 5' UTRs and therefore different regulatory properties.
22. Polyadenylation of RNAs outside of the canonical pre-mRNA pathway has been observed in certain circumstances.
23. Polyadenylation defects can lead to developmental abnormalities in organisms.
24. Polyadenylation is a sensitive mechanism that can be influenced by environmental factors such as temperature or stress.
25. The widespread application of next-generation sequencing technology has allowed for comprehensive profiling of polyadenylation events.
26. The identification of novel polyadenylation sites within certain genes has challenged previous assumptions about gene structure.
27. Modulation of polyadenylation has been proposed as a therapeutic strategy for certain diseases.
28. Alternative polyadenylation can act as a buffer against deleterious mutations in coding sequences.
29. Polyadenylation can be a dynamic process, with pre-mRNAs undergoing multiple cleavage and poly(A) addition events.
30. The mechanism of polyadenylation is highly conserved across eukaryotes.
Common Phases
1.
Polyadenylation is the process of adding a tail of adenine nucleotides to an mRNA molecule.
2. The
polyadenylation signal is a specific sequence of nucleotides within the mRNA precursor that directs the cleavage and
polyadenylation machinery to the correct location.
3.
Polyadenylation is an important step in mRNA processing that affects mRNA stability and translation efficiency.
4. Mutations in
polyadenylation signals can lead to diseases such as thalassemia and hemophilia.
5. Alternative
polyadenylation can result in different mRNA isoforms being produced from the same gene.