"Telomerase" Example Sentences
1. Telomerase is an enzyme that adds DNA sequence repeats to the end of chromosomes.
2. Abnormal activation of telomerase is a hallmark of cancer.
3. Scientists have been studying telomerase for years to try and find ways to slow the aging process.
4. Telomerase has been linked to the development of several types of cancers.
5. The discovery of telomerase won the Nobel Prize in Physiology or Medicine in 2009.
6. Without the activity of telomerase, chromosomes would progressively shorten each time a cell divides.
7. Telomerase is a key player in maintaining the length of telomeres - the protective caps at the ends of chromosomes.
8. Researchers are investigating ways to block telomerase as a potential cancer therapy.
9. Boosting telomerase activity may also have anti-aging benefits.
10. Telomerase activity declines as we age, which is linked to shorter telomeres and an increased risk of age-related diseases.
11. Multiple drugs that target telomerase are currently in clinical trials for cancer treatment.
12. The role of telomerase in stem cells is of great interest to researchers studying tissue regeneration.
13. Telomerase is present in some cells that do not divide, such as long-lived quiescent cells in the brain.
14. Telomerase inhibitors have been developed as potential treatments for chronic lymphocytic leukemia.
15. Telomerase reactivation may also play a role in tissue repair after injury.
16. Alternative lengthening of telomeres (ALT) is a mechanism by which cancer cells maintain telomere length without telomerase activity.
17. The structure of telomerase was first determined in 2018, paving the way for more targeted drug development.
18. Telomerase RNA is an essential component of the telomerase enzyme complex.
19. Telomerase mutations can cause severe disorders such as dyskeratosis congenita.
20. Development of telomerase inhibitors requires careful consideration of potential side effects on healthy cells with telomerase activity.
21. The telomerase gene hTERT is overexpressed in many cancers, making it an attractive target for therapy.
22. Inhibiting telomerase activity in combination with other cancer treatments has shown promise in preclinical studies.
23. Telomerase-based therapies may also be applicable to certain viral infections.
24. Telomerase activity can be measured in clinical samples to monitor disease progression.
25. Researchers are investigating the potential of telomerase-targeting nanoparticles for cancer theranostics.
26. Telomerase is not active in all cells, but its activity is crucial for the continued survival of cells that divide frequently.
27. Understanding the regulation of telomerase may lead to insights into the broader mechanisms of cell division and differentiation.
28. Telomerase is a unique enzyme with a complex mechanism of action, making it a challenging target for drug development.
29. Inhibiting telomerase activity may also have implications for non-cancerous diseases such as pulmonary fibrosis.
30. While telomerase has been implicated in many cancers, the diversity of its roles in different cell types and tissues is still being studied.
Common Phases
Telomerase is an enzyme; It helps maintain telomere length;
Telomerase activity declines with age; Increased
telomerase activity may lead to cancer;
Telomerase therapy is being studied as a potential anti-aging treatment.