"Tropomyosin" Example Sentences
1. Tropomyosin is a protein that plays a crucial role in regulating muscle contraction.
2. Mutations in the gene encoding tropomyosin can cause various muscle disorders.
3. The presence of tropomyosin prevents myosin from binding to actin in a relaxed muscle fiber.
4. Tropomyosin binds to actin in a way that inhibits myosin binding, keeping muscles relaxed.
5. Alternative splicing of the tropomyosin gene generates distinct isoforms with different functional properties.
6. Tropomyosin is a long, coiled-coil protein that lies along the groove of the actin filament.
7. The amino acid sequence of tropomyosin is highly conserved across many species.
8. Tropomyosin can bind to multiple sites along the actin filament, allowing for fine-tuned regulation of muscle contraction.
9. The conformation of tropomyosin is regulated by the binding of calcium ions, which can trigger muscle contraction.
10. Tropomyosin is a key component of the thin filaments that make up the sarcomeres of muscle fibers.
11. In the absence of calcium, tropomyosin blocks the myosin binding site on the actin filament.
12. Tropomyosin interacts with troponin to regulate muscle contraction in a calcium-dependent manner.
13. Changes in tropomyosin expression levels may contribute to muscle wasting or hypertrophy.
14. Tropomyosin can bind to other proteins besides actin, such as calmodulin and myosin-binding protein C.
15. Tropomyosin is required for the correct assembly of sarcomeres during muscle development.
16. The activity of tropomyosin can be modulated by various signaling pathways, such as those involving kinase enzymes.
17. Tropomyosin is a target of many disease-causing mutations and is therefore of great interest to researchers studying muscle disorders.
18. Chemical modifications of tropomyosin, such as phosphorylation or acetylation, can affect its function.
19. Proteins that interact with tropomyosin, such as caldesmon or calponin, can also regulate muscle contraction.
20. Tropomyosin plays a role in the regulation of smooth muscle function as well as skeletal muscle.
21. The differential expression of tropomyosin isoforms can have tissue-specific effects on muscle function.
22. Tropomyosin is often co-expressed with other muscle proteins such as myosin, actin, or troponin.
23. Tropomyosin is sometimes used as a marker for the identification of muscle cells in culture or tissue samples.
24. A number of drugs target the interaction between actin and tropomyosin as a means of altering muscle function.
25. Certain diseases, such as celiac disease or allergy to shellfish, may involve autoimmune reactions against tropomyosin.
26. The ability of tropomyosin to modulate actin filament dynamics may be relevant to other cellular processes besides muscle contraction.
27. Different regions of the tropomyosin molecule may have distinct functions, such as mediating interactions with specific binding partners.
28. Changes in gene expression of tropomyosin in response to exercise or injury may be important for muscle adaptation.
29. Tropomyosin can interact with proteins involved in cytoskeletal structure and vesicle transport, suggesting possible roles outside of the muscle context.
30. Studies of the crystal structure of tropomyosin have provided insights into the molecular basis of muscle function.
Common Phases
1.
Tropomyosin is a protein found in muscle cells;
2. It plays a critical role in regulating muscle contraction;
3.
Tropomyosin binds to actin filaments and blocks the binding site for myosin;
4. This helps to keep muscles relaxed when they are not being used;
5. When a nerve impulse triggers a muscle contraction,
tropomyosin moves to expose the binding site for myosin;
6. This allows the myosin to attach to the actin and pull the filaments closer together;
7. The shortening of the muscle fiber results in muscle contraction;
8.
Tropomyosin is also important for maintaining the structure and stability of actin filaments in the muscle cells;
9. Mutations in the
tropomyosin gene can lead to muscle disorders such as nemaline myopathy.