"Ubiquitylation" Example Sentences
1. Ubiquitylation is one of the key processes in protein degradation.
2. The ubiquitylation of histones is important for chromatin remodeling.
3. The E3 ligase enzyme is responsible for ubiquitylation.
4. Defects in the ubiquitylation pathway can lead to disease.
5. The role of the UPS in ubiquitylation is well-established.
6. The addition of ubiquitin via ubiquitylation signals for degradation.
7. The ubiquitylation of p53 leads to its degradation by the proteasome.
8. The ubiquitylation of misfolded proteins is crucial for maintaining protein homeostasis.
9. Ubiquitylation is often used as a target for cancer therapy.
10. There are several different types of ubiquitylation, including mono- and poly-ubiquitylation.
11. Ubiquitylation can also affect protein localization and function.
12. The ubiquitylation of key signaling components can impact cellular pathways.
13. Ubiquitylation is regulated by deubiquitylating enzymes (DUBs).
14. The ubiquitylation of transmembrane proteins can lead to their internalization and degradation.
15. Ubiquitylation can also serve as a signal for DNA repair.
16. The ubiquitylation of NF-κB subunits regulates their activity in the immune response.
17. Certain viruses have evolved mechanisms to avoid ubiquitylation and subsequent degradation.
18. Ubiquitylation-dependent regulation of protein degradation is conserved across eukaryotes.
19. The reversible nature of ubiquitylation allows for dynamic changes in protein activity.
20. The ubiquitylation of mitochondrial proteins is important for their turnover.
21. Ubiquitylation can also regulate protein-protein interactions.
22. Ubiquitylation plays a role in the development of certain neurodegenerative diseases.
23. The substrate specificity of E3 ligases is critical for proper ubiquitylation.
24. Ubiquitylation can also mark proteins for vesicular trafficking.
25. The ubiquitylation of certain proteins protects them from degradation.
26. Ubiquitylation has been implicated in the regulation of apoptosis.
27. The poly-ubiquitylation of Bax can lead to its translocation to the mitochondria and the induction of cell death.
28. The ubiquitylation of proteins involved in the DNA damage response is critical for genome stability.
29. The dysregulation of ubiquitylation can lead to cancer and other diseases.
30. The discovery of ubiquitylation has revolutionized our understanding of protein degradation.
Common Phases
1. The
ubiquitylation process is essential for regulating protein degradation;
2.
Ubiquitylation occurs when a ubiquitin molecule attaches to a protein;
3. Many proteins are targeted for
ubiquitylation by E3 ubiquitin ligases;
4. Defects in
ubiquitylation have been linked to various diseases;
5.
Ubiquitylation is involved in many cellular processes, such as DNA repair and signal transduction;
6. Researchers are studying the role of
ubiquitylation in cancer development and progression.