"Proteasome" Example Sentences
1. Proteasome inhibitors are a promising class of drugs for the treatment of cancer.
2. The proteasome is the cell's garbage disposal system, breaking down unwanted proteins.
3. Mutations in genes encoding proteasome subunits have been linked to neurodegenerative diseases.
4. The proteasome plays a critical role in controlling cell cycle progression.
5. Carfilzomib is a proteasome inhibitor that selectively targets tumor cells.
6. Impairment of proteasome function has been implicated in the development of Alzheimer's disease.
7. The proteasome is involved in the degradation of misfolded proteins that are associated with a variety of diseases.
8. Bortezomib is a proteasome inhibitor used to treat multiple myeloma.
9. The proteasome is a macromolecular complex that consists of multiple subunits.
10. Proteasome activity has been shown to decline with age, leading to accumulation of toxic protein aggregates.
11. E3 ubiquitin ligases are responsible for labeling proteins for degradation by the proteasome.
12. The proteasome is also involved in regulating the immune response by degrading foreign proteins.
13. The proteasome plays a role in maintaining protein homeostasis by eliminating damaged or misfolded proteins.
14. Proteasome dysfunction has been linked to the pathogenesis of Parkinson's disease.
15. Inhibition of proteasome activity has been a strategy for the development of new antibiotics.
16. The proteasome degrades proteins that are no longer needed, such as those involved in cell signaling pathways.
17. Proteasome subunits exhibit significant structural and functional diversity.
18. The proteasome has been identified as a potential target for the treatment of infectious diseases.
19. Proteasome inhibitors have been shown to enhance the effectiveness of chemotherapy in certain cancers.
20. Dysregulated proteasome activity has been implicated in the development of autoimmune diseases.
21. The proteasome plays a role in the regulation of gene expression by degrading transcription factors.
22. Proteasome inhibition has been shown to promote the accumulation of reactive oxygen species.
23. Mutations in genes encoding proteasome subunits have been associated with developmental disorders.
24. The proteasome is involved in the removal of oxidized and damaged proteins from the cell.
25. Proteasome activity is essential for the maintenance of protein quality control in cells.
26. The therapeutic potential of proteasome inhibition has been explored in the treatment of infectious diseases.
27. Proteasome activity is regulated by a complex network of signaling pathways.
28. Proteasome inhibition has been shown to induce cell death in cancer cells.
29. The proteasome has been identified as a hub of protein-protein interactions in the cell.
30. Proteasome inhibitors are being developed for the treatment of a variety of diseases, including Alzheimer's and Parkinson's diseases.
Common Phases
1. The
proteasome is responsible for degrading unwanted proteins;
2. Inhibition of the
proteasome can lead to the accumulation of toxic proteins;
3.
Proteasome dysfunction has been linked to various diseases, including cancer;
4. The
proteasome plays a critical role in maintaining cellular homeostasis;
5.
Proteasome inhibitors are a promising class of drugs for cancer treatment;
6. The
proteasome is composed of multiple subunits that work together to degrade proteins;
7. The
proteasome is regulated by various factors, including ubiquitin;
8.
Proteasome activity can be measured using specific assays.