"Deneddylation" Example Sentences
1. Deneddylation is a process in which the NEDD8 protein is removed from a target protein.
2. The deneddylation of cullin proteins is essential for the proper functioning of the ubiquitin-proteasome system.
3. The inhibition of deneddylation enzymes can lead to the accumulation of misfolded proteins and the development of neurodegenerative diseases.
4. Deneddylation is a reversible post-translational modification that regulates the activity of various proteins.
5. The deneddylation of the transcription factor NF-kappaB is required for its nuclear export and inactivation.
6. The deneddylation of the E2 enzyme UBE2M is necessary for the proper assembly of the ubiquitin chain.
7. Inhibition of the deneddylation of CUL1 can impair the degradation of specific target proteins.
8. Deneddylation is a crucial step in the regulation of the spindle checkpoint during mitosis.
9. The deneddylation of the E3 ligase NEDD4L is involved in the regulation of epithelial cell polarity.
10. The deneddylation of the tumor suppressor protein p53 can affect its stability and activity.
11. Deneddylation inhibitors show promise as potential anticancer agents.
12. The deneddylation of the G protein beta subunit is involved in the regulation of G protein-coupled receptor signaling.
13. Deneddylation can mediate the degradation of abnormal or damaged proteins through the proteasome system.
14. The deneddylation of the RNA-binding protein HuR can affect its subcellular localization and stability.
15. The deneddylation of the protein kinase CK2 is required for its interaction with other proteins.
16. Deneddylation of the DNA repair protein BRCA1 is important for its ability to regulate chromatin remodeling.
17. The deneddylation of the E3 ligase TRIM25 is necessary for the activation of the RIG-I signaling pathway.
18. Deneddylation has been implicated in the regulation of embryonic development and stem cell differentiation.
19. The deneddylation of the cytoskeletal protein actin is involved in the regulation of cell shape and motility.
20. Deneddylation of the transcription factor STAT3 can alter its dimerization and DNA-binding activity.
21. The deneddylation of the E3 ligase CHIP is involved in the degradation of misfolded proteins.
22. Deneddylation of the cytoskeletal protein vimentin can affect its phosphorylation and assembly into filaments.
23. The deneddylation of the transcription factor p65 is required for the induction of apoptosis in cancer cells.
24. Deneddylation of the E3 ligase MDM2 is involved in the regulation of the stability of the tumor suppressor protein p53.
25. The deneddylation of the ubiquitin-conjugating enzyme UBE2D3 is required for the proper initiation of autophagy.
26. Deneddylation of the DNA repair protein MRE11 is important for its interaction with other proteins in the DNA repair pathway.
27. The deneddylation of the E3 ligase PARK2 is involved in the regulation of mitochondrial homeostasis.
28. Deneddylation of the transcription factor NRF2 is required for its activity in the regulation of oxidative stress response.
29. The deneddylation of the E3 ligase HUWE1 is necessary for the regulation of protein turnover and stability.
30. Deneddylation of the cytoskeletal protein keratin can affect its function in the regulation of cell adhesion and migration.
31. The deneddylation of the transcription factor NF-E2-related factor 2 is involved in the regulation of antioxidant response.
32. Deneddylation of the E3 ligase RNF168 is required for the proper repair of DNA double-strand breaks.
33. The deneddylation of the kinetochore protein NDC80 is important for proper chromosome segregation during cell division.
34. Deneddylation of the transcription factor HIF-1alpha is necessary for the regulation of cellular response to hypoxia.
35. The deneddylation of the E3 ligase MARCH8 is involved in the regulation of protein trafficking and endocytosis.
36. Deneddylation has been implicated in the regulation of synaptic plasticity and memory formation.
37. The deneddylation of the immunoproteasome subunit LMP2 is required for the generation of MHC class I epitopes.
38. Deneddylation of the kinase DYRK2 is important for its interaction with other proteins in the regulation of cell cycle progression.
39. The deneddylation of the E3 ligase TRIM32 is necessary for the proper regulation of muscle homeostasis.
40. Deneddylation of the transcription factor SREBP-1c is involved in the regulation of lipid biosynthesis and metabolism.
Common Phases
1.
Deneddylation is a process of removing the NEDD8 protein;
2.
Deneddylation is necessary to regulate the activity of Cullin-RING E3 ligases;
3.
Deneddylation occurs via a deneddylase enzyme;
4.
Deneddylation plays a crucial role in controlling the cell cycle and progression;
5.
Deneddylation has been implicated in various diseases and disorders;
6.
Deneddylation is a reversible modification of proteins;
7.
Deneddylation can also affect protein stability and localization.