"Gelsolin" Example Sentences
1. Gelsolin is a protein that regulates cytoskeleton dynamics.
2. The GSN gene encodes gelsolin protein.
3. Gelsolin expression levels are altered in several diseases.
4. The function of gelsolin is critical for cell movement and adhesion.
5. Several mutations in the gelsolin gene have been linked to familial amyloidosis.
6. Gelsolin is also involved in the inflammatory response.
7. Gelsolin plays a role in wound healing and tissue repair.
8. The actin-binding site of gelsolin is critical for its function.
9. Gelsolin is a calcium-sensitive protein.
10. Gelsolin is essential for normal hearing.
11. The Lys-562-Gln variant of gelsolin has been associated with an increased risk for Alzheimer's disease.
12. Gelsolin is a promising biomarker for cancer diagnosis and prognosis.
13. Gelsolin levels are decreased in patients with Parkinson's disease.
14. Gelsolin has been proposed as a therapeutic target for cancer and neurodegenerative diseases.
15. Gelsolin interacts with several other proteins involved in cell signaling and communication.
16. The crystal structure of gelsolin has been determined using X-ray crystallography.
17. Gelsolin is activated by several factors, including calcium, pH, and lipid membranes.
18. Gelsolin is usually present as a cytoplasmic protein, but it can also be secreted.
19. The actin severing activity of gelsolin is critical for cell shape changes and migration.
20. Gelsolin is implicated in the pathogenesis of several autoimmune diseases.
21. Gelsolin can also regulate apoptosis and cell survival.
22. The GNS gene product, gelsolin, is highly conserved across different species.
23. Gelsolin is an important regulator of platelet function.
24. Gelsolin is involved in the formation of cell protrusions and filopodia.
25. The expression of gelsolin is modulated by several transcription factors.
26. Gelsolin can interact with extracellular matrix molecules, such as fibronectin and laminin.
27. The interaction between gelsolin and actin is essential for cell motility.
28. Gelsolin can be phosphorylated and acetylated, which can affect its activity.
29. Gelsolin levels can be modulated by microRNAs.
30. Gelsolin can promote cell survival in response to stress.
31. Gelsolin is a potential therapeutic target for sepsis.
32. The role of gelsolin in HIV infection is under investigation.
33. Gelsolin can also regulate the migration and invasion of cancer cells.
34. Gelsolin can be used as a therapeutic agent for acute lung injury.
35. Gelsolin can interact with several small molecules, such as polyphosphoinositides and magnesium.
36. Gelsolin can bind to several other proteins, such as profilin and cofilin.
37. The structure of gelsolin is composed of six homologous domains.
38. Gelsolin can interact with actin filaments in a cooperative manner.
39. Gelsolin can be modified by oxidation and nitrosylation, which can affect its function.
40. The function of gelsolin is critical for embryonic development.
Common Phases
1.
Gelsolin is a calcium-regulated actin-binding protein;
2. The primary function of
gelsolin is to sever actin filaments;
3.
Gelsolin also caps filament barbed ends, nucleates new filaments, and promotes actin depolymerization;
4.
Gelsolin deficiency leads to various disorders, including amyloidosis and cancer;
5.
Gelsolin acts as a tumor suppressor by inhibiting the growth and migration of cancer cells;
6.
Gelsolin participates in various cellular processes, including cytoskeletal rearrangement, cell division, and phagocytosis;
7.
Gelsolin expression is regulated by multiple signaling pathways, including Rho GTPases and PI3K/Akt;
8. Artificial manipulation of
gelsolin activity holds promise for treating various diseases.