"Primase" Example Sentences
1. Primase initiates the synthesis of RNA primers during DNA replication.
2. The activity of primase is essential for the replication of DNA.
3. Primase is an enzyme that functions in the replication fork complex.
4. The RNA primers synthesized by primase are eventually removed by DNA polymerase.
5. The rate of primase activity may vary depending on the cell type and environmental conditions.
6. The binding of primase to DNA requires a specific sequence recognition site.
7. The function of primase is linked to the stabilization of the replication fork.
8. Primase catalyzes the synthesis of short RNA sequences that serve as primers for DNA synthesis.
9. The activity of primase is regulated by several cellular factors.
10. The amount of primase present in the cell may differ depending on the phase of the cell cycle.
11. Primase is one of the key enzymes involved in DNA repair processes.
12. The interaction between primase and its substrate is highly specific.
13. Mutations in the primase gene can lead to DNA replication defects and disease.
14. The expression of primase is tightly regulated at the transcriptional and post-transcriptional levels.
15. Primase activity is tightly coordinated with the activity of other enzymes involved in DNA replication.
16. A defect in primase activity can lead to genomic instability and cancer.
17. The crystal structure of primase complexed with DNA has been determined by X-ray crystallography.
18. The role of primase in telomere repair remains poorly understood.
19. The activity of primase can be enhanced or inhibited by small molecule compounds.
20. The activity of primase is essential for the formation of Okazaki fragments during DNA replication.
21. Primase is essential for the efficient replication of mitochondrial DNA.
22. The mechanism of RNA primer synthesis by primase has been studied extensively in vitro.
23. The physical and functional interaction between primase and DNA polymerase is crucial for DNA replication.
24. Primase is involved in both leading and lagging strand synthesis during DNA replication.
25. The activity of primase is influenced by the local DNA structure and chromatin context.
26. The enzymatic activity of primase is modulated by protein-protein interactions.
27. The tight coupling between primase activity and DNA replication prevents errors and ensures fidelity.
28. The replication of telomeres requires the activity of both primase and telomerase.
29. The optimal conditions for primase activity can vary depending on the experiment and substrate.
30. The use of primase inhibitors is being explored as a potential cancer therapy strategy.
Common Phases
1.
Primase initiates RNA synthesis;
2.
Primase adds RNA primers to DNA;
3.
Primase is involved in DNA replication;
4.
Primase is a type of polymerase enzyme;
5.
Primase synthesizes short RNA segments;
6.
Primase is essential for DNA elongation;
7.
Primase precedes DNA polymerase activity;
8.
Primase plays a crucial role in DNA repair;
9.
Primase is responsible for synthesizing the primer strand;
10.
Primase activity is regulated by other proteins.