"Primases" Example Sentences
1. Primases are enzymes that synthesize RNA primers for DNA replication.
2. The activity of primases is required for the initiation of DNA replication.
3. Mutations in the primase gene can lead to defects in DNA replication.
4. The binding of primases to DNA is mediated by specific protein-protein interactions.
5. Primases are among the most important factors involved in the regulation of DNA replication.
6. The RNA primers synthesized by primases are essential for the elongation of DNA chains by DNA polymerases.
7. Many bacterial primases are small, single-domain proteins that do not require additional subunits for activity.
8. Eukaryotic primases are typically larger and more complex than bacterial primases.
9. The activity of primases can be modulated by various regulatory factors, including DNA helicases and single-stranded DNA binding proteins.
10. One of the main functions of primases is to ensure that DNA replication proceeds smoothly and quickly.
11. Some primases are able to synthesize RNA primers on both the leading and lagging strands of DNA.
12. The efficiency of DNA replication is strongly influenced by the activity of primases and other DNA replication proteins.
13. Primases are highly conserved among different organisms, indicating their essential role in DNA replication.
14. Some viruses encode their own primases to ensure efficient replication of their DNA or RNA genomes.
15. The structure of primases has been studied in detail by X-ray crystallography and other techniques.
16. Recent studies have identified new factors that interact with primases and modulate their activity.
17. The ability of primases to recognize specific DNA sequences is essential for their function in DNA replication.
18. Primases can be a target for antiviral drugs that inhibit viral replication.
19. The catalytic site of primases is highly conserved among different types of organisms.
20. The activity of eukaryotic primases is regulated by various post-translational modifications, including phosphorylation and acetylation.
21. Some primases are able to recognize unusual DNA structures, such as G-quadruplexes, that can interfere with normal DNA replication.
22. The activity of primases is tightly regulated to ensure that DNA replication occurs only once per cell cycle.
23. In some organisms, the primase function is combined with the helicase function in a single protein.
24. Some primases are able to synthesize RNA primers that are longer than the typical 10 nucleotides, indicating their flexibility in adapting to different situations.
25. The crystal structure of a bacterial primase showed that it has a unique fold that is different from other RNA polymerases.
26. Synthetic primases have been designed to enhance DNA replication in vitro.
27. The activity of primases can be inhibited by certain toxins, such as rifampicin, that are used as antibiotics.
28. DNA replication factories, or replisomes, contain several primases along with other DNA replication proteins.
29. The rate of DNA replication is strongly influenced by the speed and accuracy of primases and other DNA replication proteins.
30. Understanding the structure and function of primases is essential for developing new treatments for genetic diseases and viral infections.
Common Phases
1.
Primases are enzymes that synthesize RNA primers;
2. During DNA replication,
primases play a crucial role in initiating DNA synthesis;
3.
Primases require a template strand and a free 3'-OH group to initiate RNA primer synthesis;
4. DNA polymerases use RNA primers synthesized by
primases as a starting point for DNA synthesis;
5. Mutations in
primases have been linked to various diseases, including cancer.