"Spectrin" Example Sentences
1. Spectrin is an essential protein for the structural integrity of red blood cells.
2. Mutations in the spectrin gene can lead to hereditary spherocytosis, a type of anemia.
3. Spectrin forms a mesh-like network that gives cell membranes their strength and flexibility.
4. The spectrin cytoskeleton is necessary for maintaining the shape and stability of many different types of cells.
5. Spectrin interacts with other proteins to maintain the barrier function of the blood-brain barrier.
6. Spectrin is a key component of the postsynaptic density in neurons.
7. Spectrin mutations are associated with a range of neurological disorders, including epilepsy and autism.
8. Spectrin is also found in non-erythroid cells, where it plays a role in cell adhesion and motility.
9. Spectrin can undergo post-translational modifications such as phosphorylation and glycosylation.
10. Spectrin-deficient mice have defects in blood vessel formation and neural development.
11. Spectrin is essential for the proper segmentation of the zebrafish embryo.
12. Spectrin can be purified from red blood cells and used for in vitro studies of protein-protein interactions.
13. Spectrin has been shown to interact with lipid rafts in the plasma membrane.
14. Spectrin mutations can cause defects in axonal transport and synaptic plasticity.
15. Spectrin is a target of several viruses and bacteria, including malaria and Group A Streptococcus.
16. Spectrin is involved in the recruitment and organization of signaling molecules in T cells.
17. Spectrin can be used as a biomarker for certain types of cancer.
18. Spectrin has been studied as a potential therapeutic target for autoimmune and inflammatory diseases.
19. Spectrin has been shown to interact with cytoplasmic dynein and kinesin-1 in neuronal transport.
20. Spectrin is required for the proper formation and function of the neuromuscular junction.
21. Spectrin can be found in non-mammalian species, such as chicken and zebrafish.
22. Spectrin is involved in the regulation of ion channels and neurotransmitter receptors in neurons.
23. Spectrin can act as a scaffold for the assembly of other cytoskeletal proteins.
24. Spectrin interacts with various cytoplasmic and transmembrane proteins to maintain cell morphology and function.
25. Spectrin can be cleaved by proteases such as calpain and caspase-3.
26. Spectrin mutations can lead to abnormal red blood cell morphology and increased susceptibility to oxidative stress.
27. Spectrin can be detected in cerebrospinal fluid and may be a useful biomarker for traumatic brain injury.
28. Spectrin is involved in the regulation of glucose transport in adipocytes.
29. Spectrin is required for the proper trafficking of AMPA receptors in neurons.
30. Spectrin can be used to measure the elasticity and stability of red blood cells.
31. Spectrin has been shown to modulate the activity of voltage-gated channels in neurons.
32. Spectrin plays a crucial role in the stabilization of synapses and dendritic spines in the brain.
33. Spectrin is required for the proper formation and function of the immunological synapse.
34. Spectrin can be degraded by autophagy in response to cellular stress.
35. Spectrin is necessary for the maintenance of neuronal polarity and axonal growth.
36. Spectrin can interact with actin and tubulin to regulate cytoskeletal dynamics.
37. Spectrin mutations can cause defects in the development and function of the inner ear.
38. Spectrin can undergo conformational changes in response to changes in membrane tension.
39. Spectrin is involved in the regulation of intracellular calcium signaling.
40. Spectrin can be modified by reactive oxygen species and may play a role in oxidative stress responses.
Common Phases
1.
Spectrin is a major component of the cytoskeleton;
2.
Spectrin provides support and shape to red blood cells;
3. Mutations in
spectrin genes can cause certain types of hereditary anemias;
4.
Spectrin plays a critical role in maintaining membrane stability and function;
5.
Spectrin has also been implicated in several neurological diseases;
6.
Spectrin interacts with a variety of proteins and lipids within the cell membrane;
7.
Spectrin can undergo post-translational modifications that influence its function.