"Ubiquityl" Example Sentences
1. The ubiquityl transferase enzyme plays a crucial role in protein degradation.
2. Ubiquitylation is the process of adding a ubiquityl group to a protein molecule.
3. Researchers have identified a new type of ubiquityl ligase that targets specific proteins.
4. The ubiquityl-proteasome pathway is a major mechanism for regulated protein degradation.
5. Mutations in genes encoding ubiquityl ligases have been linked to various diseases.
6. Ubiquitylation can be reversed by deubiquitylating enzymes.
7. Ubiquityl chains can have different structures and lengths, which affects their biological function.
8. The ubiquityl system has been implicated in many cellular processes beyond protein degradation.
9. Proteins that escape ubiquitylation are known as deubiquitylated.
10. The role of ubiquitylation in DNA damage response is still unclear.
11. Studies have shown that aberrant ubiquitylation contributes to neurodegeneration.
12. Ubiquitylation of histones is involved in transcriptional regulation.
13. Ubiquitylation has been linked to cancer development and progression.
14. Ubiquitylation can regulate protein stability, localization, and interactions with other molecules.
15. The ubiquitylome is the entire set of ubiquitylated proteins in a given cell or tissue.
16. The specificity of ubiquitylation is determined by the ubiquityl ligase and its substrate recognition domain.
17. The cellular fate of a ubiquitylated protein depends on the chain length and topology of ubiquityl chains.
18. Ubiquitylation can occur on various amino acid residues, such as lysine and serine.
19. Defects in proteasome function can lead to accumulation of ubiquitylated proteins and protein aggregates.
20. The ubiquitylation signal can be recognized by adaptors that recruit ubiquitylated proteins to specific cellular locations or complexes.
21. Ubiquitylation can occur on membrane proteins, leading to their internalization and eventual degradation.
22. The study of ubiquitylation has led to the discovery of novel degradation pathways, such as autophagy.
23. The role of ubiquitylation in cell signaling and inflammation is an area of active research.
24. Some viruses have evolved mechanisms to evade ubiquitylation and proteasome-mediated degradation.
25. The ubiquityl ligase CHIP is involved in quality control of cellular proteins and misfolded species.
26. The cellular concentration of ubiquitylated proteins can be regulated by deubiquitylating enzymes.
27. The ubiquitylation state of a protein can influence its interaction with other proteins and biological activity.
28. Ubiquitylation can be used as a tool to modify protein function or stability in research and biotechnology.
29. The regulation of ubiquitylation is complex and involves multiple enzymes, cofactors, and signaling pathways.
30. The ubiquityl system is essential for proper cell function and development, and disruption of this system can lead to disease.
Common Phases
1.
Ubiquitylation plays a crucial role in protein degradation;
2.
Ubiquitylation also regulates cellular processes such as DNA repair and signal transduction;
3.
Ubiquitylation is mediated by a complex machinery of enzymes and substrate recognition factors;
4. The addition of ubiquitin to target proteins is reversible through de
ubiquitylation enzymes;
5. Aberrant
ubiquitylation has been implicated in various human diseases including cancer, neurodegeneration, and inflammation.