"Ubiquitylase" Example Sentences
1. Researchers have discovered a new type of ubiquitylase that selectively targets specific proteins.
2. The degradation of misfolded proteins is primarily regulated by the activity of the ubiquitylase system.
3. Deficiencies in certain classes of ubiquitylases have been linked to neurodegenerative diseases.
4. Ubiquitylases have emerged as important therapeutic targets for the treatment of cancer.
5. The study of ubiquitylases has led to the development of new compounds that can modulate protein degradation.
6. Ubiquitylases are enzymes that catalyze the attachment of ubiquitin to other cellular proteins.
7. The ubiquitylase Parkin is mutated in some cases of hereditary Parkinson's disease.
8. Proteasome inhibitors are used to block the activity of the ubiquitylase system, leading to accumulation of proteins.
9. Several E3 ubiquitylases are involved in the regulation of cell cycle progression.
10. The role of ubiquitylases in the regulation of gene expression has only recently been appreciated.
11. Ubiquitylases play a critical role in the maintenance of protein homeostasis in the cell.
12. The activity of ubiquitylases is tightly regulated by other proteins and post-translational modifications.
13. Some of the most important ubiquitylases are localized to the endoplasmic reticulum and Golgi apparatus.
14. The ubiquitylase TRIM50 has been implicated in the regulation of DNA damage response pathways.
15. Certain types of DNA damage can induce the activation of specific ubiquitylases.
16. Ubiquitylases are also involved in the regulation of immune responses to pathogens.
17. The structure of some ubiquitylases suggests that they may be used as targets for the development of small molecule inhibitors.
18. The specificity of ubiquitylases is determined by their interactions with other regulatory proteins.
19. The loss of certain ubiquitylases can lead to the accumulation of misfolded proteins and the development of disease.
20. Many types of cancers are associated with dysregulation of ubiquitylase activity.
21. The ubiquitylase RNF146 plays a role in the regulation of axon branching during neuronal development.
22. The ubiquitylase TRIM28 is involved in the regulation of embryonic stem cell differentiation.
23. The process of ubiquitylation can also be reversed by specialized enzymes called deubiquitylases.
24. Deficiencies in certain deubiquitylases have been linked to inflammatory bowel disease.
25. The activity of deubiquitylases is also closely regulated in the cell.
26. Ubiquitylation and deubiquitylation are dynamic processes that are crucial for maintaining cellular homeostasis.
27. The crosstalk between different classes of ubiquitylases and deubiquitylases adds another layer of complexity to this system.
28. The ubiquitylase UBR5 has been implicated in the regulation of autophagy pathways.
29. The development of new tools for studying the ubiquitylation system has greatly increased our understanding of this process.
30. The ubiquitylation system is an important target for the development of new therapies for a wide range of diseases.
Common Phases
1. The
ubiquitylase enzyme plays a crucial role in protein degradation;
2. Mutations in the
ubiquitylase gene have been linked to various diseases;
3. The function of the
ubiquitylase pathway is to mark proteins for destruction;
4. Dysregulation of the
ubiquitylase system can lead to the accumulation of abnormal proteins in cells;
5. Ubiquitylation is a multi-step process involving several
ubiquitylase enzymes;
6. The discovery of ubiquitylation and
ubiquitylase has opened up new areas of research in cell biology;
7. Some cancer therapies are designed to target specific
ubiquitylase enzymes.