"Helicases" Example Sentences
1. The function of helicases is to unwind the DNA double helix.
2. Helicases are critical enzymes involved in DNA replication.
3. The activity of helicases is essential for proper chromosome segregation during cell division.
4. Mutations in the helicase genes can lead to severe developmental disorders.
5. Helicases are often targeted by anti-viral drugs to prevent viral replication.
6. Helicases play a crucial role in DNA repair by unwinding damaged fragments.
7. The DNA helicases can distinguish between single-stranded and double-stranded DNA.
8. Helicases are ATP-dependent and utilize energy to translocate along the DNA molecule.
9. The unwinding activity of helicases can be stimulated by the presence of accessory proteins.
10. Helicases can bind to specific DNA sequences to facilitate DNA replication and repair.
11. The DNA helicases are highly conserved across species, indicating their fundamental importance.
12. Helicases are classified into different families based on their structural and functional characteristics.
13. Helicases exhibit different substrate specificities and are involved in various cellular processes.
14. The activity of helicases can be regulated by post-translational modifications such as phosphorylation.
15. Helicases can function to remodel nucleosomes, which are the basic units of chromatin structure.
16. Helicases are involved in homologous recombination, a process essential for genetic diversity.
17. The human genome contains over 100 different helicase genes.
18. Helicases have been implicated in the pathogenesis of cancer due to their role in DNA damage response.
19. The DNA replication fork is stabilized by the action of helicases and other proteins.
20. Helicases can act as molecular motors, moving along DNA substrates to carry out their functions.
21. The activity of helicases can be inhibited by small molecules that bind to their active sites.
22. The unwinding of DNA by helicases generates single-stranded DNA, which can be stabilized by binding proteins.
23. Helicases can interact with RNA molecules, indicating their involvement in RNA processing.
24. The crystal structure of some helicases has been elucidated, providing insights into their mechanisms of action.
25. Helicases are essential for the proper functioning of telomeres, the protective caps at the ends of chromosomes.
26. Some viruses encode their own helicases to facilitate their replication within host cells.
27. Helicases can act as sensors of DNA damage, initiating appropriate cellular responses.
28. The functional diversity of helicases is reflected by their distinct cellular localizations.
29. The helicase activity can be modulated by altering its accessibility to DNA substrates.
30. Helicases are promising targets for the development of novel therapeutics for a variety of diseases.
Common Phases
1.
Helicases unwind double-stranded DNA;
2.
Helicases are involved in DNA replication;
3.
Helicases are important for repair of damaged DNA;
4.
Helicases play a role in RNA transcription;
5.
Helicases are essential for ribosome assembly;
6.
Helicases are necessary for viral genome replication;
7. Mutations in helicase genes can lead to genetic diseases.