"Importins" Example Sentences
1. The cytoplasmic localization of proteins is determined by the importins.
2. Nuclear localization signals are recognized by importins alpha and beta.
3. The cargo-binding domain of importins alpha is different from that of beta.
4. Importins are essential for nuclear import of transcription factors.
5. The importins form a protein complex with the nuclear pore complex.
6. Defects in importin function can cause neurodegenerative diseases.
7. The role of importins in viral infections is still poorly understood.
8. The nuclear import of ribosomal proteins requires specific importins.
9. The formation of stable importin-cargo complexes is crucial for nuclear import.
10. The importin system is conserved across different kingdoms of life.
11. Cargo proteins are delivered to the nucleus by importins in a GTP-independent manner.
12. The binding affinity of importins can be modulated by post-translational modifications.
13. The interaction between importins and nuclear pore proteins is crucial for nuclear import.
14. Different importins have different substrate specificities.
15. Importins can also regulate gene expression by controlling the nuclear export of transcription factors.
16. The localization of centromeres during mitosis is mediated by importins.
17. Importins are not only involved in nuclear import but also in spindle organization during cell division.
18. The importin pathway is critical for the proper expression of developmental genes.
19. The nuclear import of epigenetic modifiers requires importins.
20. Importins have been implicated in tumorigenesis through their effect on gene expression.
21. Importins interact with Ran GTPase to mediate nuclear transport.
22. Disruption of the importin pathway can lead to abnormalities in cell differentiation.
23. The interaction between importins and cargo proteins is regulated by phosphorylation.
24. The localization of mRNAs within the cytoplasm is also regulated by importins.
25. Importins can shuttle between the nucleus and cytoplasm depending on cellular demands.
26. The effect of importins on gene expression can be modulated by stress stimuli.
27. The importin-mediated pathway is essential for the development of the nervous system.
28. Some importins can also regulate mRNA splicing within the nucleus.
29. The localization of membrane proteins is also regulated by importins.
30. Importins can also play a role in DNA damage response.
31. The expression of certain oncogenes is regulated by importins.
32. The interaction between importins and cargo proteins is oligomeric in nature.
33. Importins also interact with the nuclear lamina to regulate nuclear architecture.
34. The interaction between importins and cargo proteins can undergo conformational changes during nuclear transport.
35. Importins can interact with different nuclear transport receptors to transport cargo proteins.
36. The importin pathway is highly conserved and is essential for eukaryotic life.
37. Disruption of the importin pathway can lead to developmental abnormalities.
38. The importin pathway is also involved in regulating RNA metabolism within the nucleus.
39. The interaction between importins and cargo proteins is also regulated by the availability of Ran GTPase.
40. Importins can also play a role in autophagy.
Common Phases
1.
Importins facilitate the nuclear import of proteins;
2.
Importins are mediated by Ran-GTP;
3.
Importins bind to nuclear localization signals (NLS) on cargo proteins;
4.
Importins transport the cargo protein through nuclear pore complexes;
5.
Importins release the cargo protein in the nucleus.