"Acetylcholinesterases" Example Sentences
1. The activity of acetylcholinesterases plays a key role in the regulation of neurotransmitter signals.
2. Inhibition of acetylcholinesterases is a common therapeutic approach for Alzheimer's disease.
3. Acetylcholinesterases are found in high concentrations in the central nervous system.
4. Pesticides can interfere with the activity of acetylcholinesterases in insects and other organisms.
5. The rate of breakdown of acetylcholine is largely determined by acetylcholinesterases.
6. Certain nerve agents bind irreversibly to acetylcholinesterases, leading to a buildup of acetylcholine.
7. The activity of acetylcholinesterases is regulated by a variety of mechanisms, including phosphorylation and proteolysis.
8. The development of specific agonists and antagonists for acetylcholinesterases has been a major focus of drug discovery efforts.
9. The binding site for acetylcholine on acetylcholinesterases is highly conserved across species.
10. Mutations in the genes encoding acetylcholinesterases can lead to various neuromuscular disorders.
11. The precise mechanism of action of acetylcholinesterases is still not fully understood.
12. Acetylcholinesterases are highly responsive to changes in cellular calcium levels.
13. Some snakes produce deadly toxins that affect the activity of acetylcholinesterases in prey.
14. Acetylcholinesterases are expressed by a variety of different cell types throughout the body.
15. The kinetics of acetylcholinesterases have been extensively studied in vitro and in vivo.
16. Certain pharmacological agents can inhibit or block the activity of acetylcholinesterases.
17. Acetylcholinesterases are involved in the regulation of cardiovascular function and other physiological processes.
18. The binding of acetylcholine to acetylcholinesterases induces a conformational change that promotes catalysis.
19. Acetylcholinesterases are subject to a variety of regulatory proteins and other factors that modulate their activity.
20. The activity of acetylcholinesterases can be selectively inhibited by certain compounds, such as neostigmine.
21. Acetylcholinesterases are a key target for the development of new diagnostic and therapeutic technologies.
22. Inhibition of acetylcholinesterases can lead to an accumulation of acetylcholine, resulting in overstimulation of the nervous system.
23. The activity of acetylcholinesterases is closely linked to that of other enzymes and signaling molecules in the brain.
24. Prolonged exposure to certain environmental toxins can lead to chronic dysfunction of acetylcholinesterases.
25. Acetylcholinesterases are essential for normal functioning of the neuromuscular junction and other synapses.
26. Some bacteria produce toxins that specifically target acetylcholinesterases, leading to paralysis and other symptoms.
27. Acetylcholinesterases are an important biomarker for the diagnosis and monitoring of certain neurological disorders.
28. Alterations in the expression or activity of acetylcholinesterases can have widespread effects on neurotransmission and other cellular processes.
29. The molecular structure of acetylcholinesterases has been extensively characterized using X-ray crystallography and other methods.
30. The therapeutic potential of acetylcholinesterases as drug targets is being explored in a variety of fields, including oncology and infectious disease.
Common Phases
1.
Acetylcholinesterases play a crucial role in regulating synaptic transmission;
2. The inhibition of
acetylcholinesterases can lead to accumulation of acetylcholine, resulting in excessive stimulation;
3. Certain drugs target
acetylcholinesterases to treat conditions such as Alzheimer's disease;
4.
Acetylcholinesterases are found in the nervous system, muscles, and some non-neuronal tissues;
5. Pesticides such as organophosphates and carbamates can also inhibit
acetylcholinesterases.